Immune-mediated toxicity - Activation of NADPH and MAPK

3 important questions on Immune-mediated toxicity - Activation of NADPH and MAPK

What specific patterns can activate the DAMPs?

‘Damage’-Associated Molecular Patterns trigger innate immune response
  • Mitochondrial DNA – CpG repeats

What can activate the MAPK-pathway?


Heel veel routes maar ook:
  • Polymorphonuclear neutrophils.
  • ROS

The MAPK-pathway; what does it activate?

Meerdere pathways => maar ook immuungerelateerd.
JNK en p38

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