Mitochondrial toxicity and autophagy - Pertubation by xenobiotics - ETC inhibition
5 important questions on Mitochondrial toxicity and autophagy - Pertubation by xenobiotics - ETC inhibition
Explain one inhibitors of complex 1 in detail. Which disease is related to this?
- inhibits the transfer of electrons from ironsulfur centers in complex I to ubiquinone (eind acceptator in complex I)
- inhibition of oxidative phosphorylation
- ATP depletion
- resulting in cell death.
Parkinson! => mtDNA damage because of ROS becaus of incomplete electron transfer.
What is a complex III inhibitor?
- Fish poison
- Binds to the Q domain of complex III
- blocks the electron transport from cytochrome b to cytochrome c
What is a complex IV inhibitor?
- Attaches to iron atom
- block transport
- high affinity binding
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What is a complex V inhibitor?
- ATP synthase
- high levels of lactate
- Blocks polypeptide F0 subunit, needed for ATP production from ADP.
- Prevents protons from passing back into the mitochondria The concentration gradient becomes very large proton pump stopped Electron flow is significantly reduced
What causes mtDNA depletion?
The question on the page originate from the summary of the following study material:
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