Immune-mediated toxicity - The liver and bioactivation
3 important questions on Immune-mediated toxicity - The liver and bioactivation
So the liver is important for drug metabolism. How is the immune system related?
The liver has specific macrophages => kupffer cells
15% of total number of liver cells.
15% of total number of liver cells.
Are Kupffer cells always doing a good job? Name relevant examples.
- Carbon tetrachloride (CCl₄): metabolized -> production of radicals. -> damage of hepatocytes.
- This activates DAMPS => activates kupffer cells => release of cytokines and ROS.
The liver is important for bioactivation.
- However there is an interplay with immune cells?
- How?
- Give an example.
- Neutrophils can also make reactive metabolites.
- By myeloperoxidase
- Clozapine. Clozapine +Myeloperoxidase = Reactive Metabolite => Results in agranulocytosis
Neutrofielen (en een beetje macrofagen) produceren myeloperoxidase.
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