Lecture title - Analgesia and Hyperalgesia - Endogenous analgesic (pain-suppressing) neuropeptides

5 important questions on Lecture title - Analgesia and Hyperalgesia - Endogenous analgesic (pain-suppressing) neuropeptides

What is the collective name of analgesia chemicals?
What kind of chemicals are these, what is their function?

endogenous analgesics - act as neuromodulators to physically block pain signals within your neural circuits
endogenous opiates or opioids.

What are the four primary types of these pain-suppressing neuropeptides (endrogenous analgesics) called endogenous opiates or opioids.

  1. Enkephalins
  2. Endorphins
  3. Dynorphins
  4. Endomorphins

Of the 4 pain supressing opioids, Enkephalins, Endorphins, Dynorphins and Endomorphins, which is “runners high”?
What produces this?

Endorphins
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How do endogenous analgesic (pain-suppressing) neuropeptides like Enkephalins, Endorphins, Dynorphins and Endomorphins work?

bind to their specific opioid receptors found throughout the brain and spinal cord

What are the 4 types of opioid receptors?
Where in the CNS are there receptors found?

  1. Mu, neural pathways communitcating pain
  2. Delta, limbic system dictating emotion
  3. Kappa, celebral cortex and pathways communicating the sedative effects of opiates
  4. Sigma, hippocampus
  5. Epilson, base of the brain and hypothalamus

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